Festival creator Adam Zacks founded Sasquatch! in 2002 with the aim of constructing an event that catered to the eclectic tastes of voracious music enthusiasts. Zacks personally curates the lineups for each Sasquatch! Festival, hand-picking the diverse array of artists. "It's our goal each year to present a fresh line up that reflects the independent spirit of the Pacific Northwest, respects the artists and audience, and celebrates the grandeur of The Gorge."

The Sasquatch! Festival has established a tradition of presenting critically acclaimed emerging artists alongside established headliners. Previous lineups have spanned a broad spectrum of genres from rock to hip-hop, electronic to singer-songwriters; past performers include R.E.M. Coldplay, Kanye West, Beastie Boys, Nine Inch Nails, Wilco, The Flaming Lips, The Cure, Björk, and M.I.A. The festival also has a history of incorporating comedy including performances by Flight of The Conchords, Zach Galifianakis, Sarah Silverman, and many more.