In 2007, Keenan created Puscifer, a multifaceted, multimedia, multi-artist, and multi-personality project self-described as "a physical manifestation of the party that goes on in my head 24/7." The collective's debut, V is for V*****, was followed by a remix album (V is for V*****) as well as several singles and videos featuring the curvaceous Queen B. A rotating cast of players involved in the recordings include Mat Mitchell, Tim Alexander, Jonny Polonsky, Danny Lohner, Gil and Rani Sharone, Lustmord, Laura Milligan, Milla Jovovich, Lisa Germano, and Alan Moulder.

"Expect a loosely organized bucket of Romper Room chaos sprinkled with Dry Wit and Brown Note Booty Bumping Sub Bins. And perhaps some snacks." said Keenan.