The joke focused on something fans probably don't want to think about: the possibility that the four guys could eventually replace Zayn in the lineup. Of course, the remaining 1D-ers, Louis Tomlinson, Niall Horan, Harry Styles and Liam Payne, have said they have no plans to find a new member, but who can help but joke about the prospect?

Certainly not Amy Schumer, who poked fun at another big announcement that happened Sunday. "Of course, I have to mention the big news today," Schumer told the crowd. 'After months of speculation, Hillary Clinton finally announced she's taking Zayn's spot in One Direction. The first woman in One Direction. I never thought I'd live to see the day!"