Hetfield was joined by Alice In Chains guitarist Jerry Cantrell, Red Hot Chili Peppers drummer Chad Smith and a pedal steel guitarist for the song; the lineup also performed the Metallica track "Mama Said" from 1996's "Load."

The Metallica guitarist and lead singer also delivered an acoustic version of Adele's "Crazy For You" - from 2008's "19" - with his 16 year-old daughter Cali on vocals.

Hetfield and Sammy Hagar co-hosted the event, which also included performances by Joe Satriani, Pat Monahan from Train, Adam Sandler and Linda Perry.

All proceeds from "Acoustic-4-A-Cure" will be donated to fund children's brain tumor research at UCSF Benioff Children's Hospital, one of the nation's leading children's medical facilities. Watch videos of the performances - here.

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