He also was the co-creator of The Simpsons, one of the most enduring and long-running shows in TV history. Besides that, he was also a guy who cared a lot about animals, mainly dogs.

He started the Sam Simon Foundation to provide a variety of free surgeries to cats and dogs belonging to low-income families, as well as to rescue dogs from shelters and humane societies to become hearing dogs for those who are deaf or hard of hearing.

Upon hearing of his passing, Simpsons co-creator Al Jean tweeted, "If you would like to honor Sam's memory, do something nice for the next animal you meet. An enormous loss."